Techniques
The lab combines chronic large-scale electrophysiological and two-photon imaging recordings with traditional and holographic optogenetic manipulations, using the mouse as a model system. We seek to understand how the evolution of parallel neural pathways has contributed to the spectacular development of the associative skills that characterize mammalian behaviour. We develop novel behavioural paradigms and precise tools to monitor drugs’ pharmacodynamic effects on the neural circuitry.
High-density electrophysiology
Multichannel recordings from head-fixed and freely-moving mice
Imaging
Chronic two-photon, wide-field, and intrinsic imaging
Optogenetics and chemogenetics
Single and two-photon optogenetic and chemogenetic manipulations
Behaviour
Behavioural paradigms in virtual reality and open arenas
In vivo whole-cell recordings
Patch-clamp recordings in head-fixed
awake and anesthetized mice
